A New Polymorph of Metacetamol Full article
Journal |
CrystEngComm
ISSN: 1466-8033 |
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Output data | Year: 2015, Volume: 17, Number: 32, Pages: 6183-6192 Pages count : 10 DOI: 10.1039/c5ce00910c | ||||||||||
Tags | INDUCED LIVER-INJURY; NONHEPATOTOXIC REGIOISOMER; ORTHORHOMBIC PARACETAMOL; PARA-HYDROXYACETANILIDE; HIGH-PRESSURE; MOUSE-LIVER; ACETAMINOPHEN; FORMS; AMAP; 3'-HYDROXYACETANILIDE | ||||||||||
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Abstract:
Metacetamol is a structural isomer of the widely used drug paracetamol and is being considered as a promising alternative to the latter because of its lower toxicity. Due to the importance of the well-known polymorphism of paracetamol, an investigation of the polymorphism of metacetamol was successfully undertaken. A new polymorph of metacetamol has been discovered and extensively characterised using a variety of analytical techniques (IR- and Raman spectroscopy, UV-visible optical spectroscopy, X-ray powder and single-crystal diffraction, TGA and DSC). A procedure for the reliable and reproducible preparation of the new polymorph is described. Its properties and crystal structure are compared with those of the previously known polymorph, as well as with those of paracetamol.
Cite:
McGregor L.
, Rychkov D.A.
, Coster P.L.
, Day S.
, Drebushchak V.A.
, Achkasov A.F.
, Nichol G.S.
, Pulham C.R.
, Boldyreva E.V.
A New Polymorph of Metacetamol
CrystEngComm. 2015. V.17. N32. P.6183-6192. DOI: 10.1039/c5ce00910c WOS Scopus РИНЦ ANCAN OpenAlex
A New Polymorph of Metacetamol
CrystEngComm. 2015. V.17. N32. P.6183-6192. DOI: 10.1039/c5ce00910c WOS Scopus РИНЦ ANCAN OpenAlex
Files:
Full text from publisher
Dates:
Submitted: | May 8, 2015 |
Accepted: | Jul 12, 2015 |
Published online: | Jul 14, 2015 |
Identifiers:
Web of science: | WOS:000358915300015 |
Scopus: | 2-s2.0-84938490728 |
Elibrary: | 23995688 |
Chemical Abstracts: | 2015:1161440 |
Chemical Abstracts (print): | 168:311493 |
OpenAlex: | W2111755688 |